The Derby d’Italia is the huge game of the afternoon as Juventus seek revenge against Inter for the end of their 49-game unbeaten record.
It kicks off at San Siro at 14.00 GMT, click here for a match preview.
The Bianconeri had gone without defeat for 49 consecutive Serie A rounds before suffering a shock 3-1 home loss at the hands of their rivals back on November 3.
Antonio Conte’s men hope to return the favour at the Stadio Meazza, where they are unbeaten since April 2010.
Mirko Vucinic was a last-minute absentee due to flu symptoms, joining the injured Martin Caceres, Simone Pepe, Mauricio Isla and Nicklas Bendtner.
Giorgio Chiellini pulled out of international duty last week with ankle problems, but is able to start this match.
Fabio Quagliarella surprisingly starts with Alessandro Matri in attack, while Simone Padoin replaces Stephan Lichtsteiner ahead of the Champions League quarter-final with Bayern Munich.
Inter have numerous problems to contend with, as Juan Jesus is suspended, while Fredy Guarin returned late from international duty after missing his flight.
Dejan Stankovic, Diego Milito, Luca Castellazzi, Joel Obi and Gaby Mudingayi are all long-term absentees, but Walter Samuel is back in the starting XI after an injury lay-off for a three-man defence.
Rodrigo Palacio partners Antonio Cassano with support from Ricky Alvarez and the Italian has an excellent record against Juve, scoring seven goals past them in 18 games.
Inter: Handanovic; Ranocchia, Samuel, Chivu; Zanetti, Kovacic, Gargano, Pereira; Alvarez; Palacio, Cassano
Inter bench: Belec, Carrizo, Silvestre, Guarin, Kuzmanovic, Rocchi, Cambiasso, Benassi, Jonathan, Pasa, Nagatomo
Juventus: Buffon; Barzagli, Bonucci, Chiellini; Padoin, Vidal, Pirlo, Marchisio, Asamoah; Quagliarella, Matri
Juventus bench: Storari, Rubinho, Pogba, De Ceglie, Giovinco, Peluso, Anelka, Giaccherini, Marrone
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!