There is still no place in the Lazio starting XI for Miroslav Klose, as Libor Kozak starts up front against Fenerbahce.
The Czech striker will the lead the line on his own against the Turkish outfit, as the Biancocelesti travel to Istanbul for the quarter-finals of the Europa League.
Elsewhere, Vladimir Petkovic has opted for a back-four, with Michael Ciani, Lorik Cana, Stefan Radu and Alvaro Gonzalez.
For the home team meanwhile, they have opted for former Premier League stars Joseph Yobo, Dirk Kuyt and Raul Meireles.
Fenerbahce: Demirel; Gonul, Yobo, Korkmaz, Ziegler; Topal, Meireles; Kuyt, Cristian, Sow; Webo
Lazio: Marchetti; Ciani, Cana, Radu, Gonzalez; Candreva, Onazi, Hernanes, Lulic; Ederson; Kozak