Nenad Krsticic has joined the injury list, leaving Sampdoria with problems in midfield against Palermo.
The Blucerchiati host the Rosanero on Sunday afternoon at 14.00 UK time (13.00 GMT). Click here for a match preview.
Coach Delio Rossi already had to deal with the absence of Andrea Poli due to suspension, but has now also lost Krsticic in the same area of the park.
He picked up a muscular problem in his right thigh during training and the official Sampdoria website confirmed Krsticic is also at risk for the Genoa Derby on April 14.
Eder returns from his ban, as does Andrea Costa from injury.
Sampdoria squad for Palermo: Berni, Da Costa, Romero; Berardi, Castellini, Costa, De Silvestri, Gastaldello, Mustafi, Poulsen, Rodríguez, Rossini; Maresca, Munari, Obiang, Palombo, Renan, Soriano; Eder, Estigarribia, Icardi, Maxi Lopez, Sansone