The Derby della Lanterna is also a relegation dogfight that sees Sampdoria seek revenge on Genoa by sending them towards Serie B.
Marassi will light up for this afternoon’s Genoa Derby, click here for a match preview.
Genoa are looking increasingly desperate, as going into this weekend they were in joint-penultimate position with Palermo and Siena, managing two points from the last six rounds.
Thomas Manfredini returns from suspension and Juraj Kucka has shaken off a knock, but Cesare Bovo, Marco Rossi and Damiano Ferronetti miss out.
Marco Borriello partners Ciro Immobile in attack.
Sampdoria have Andrea Poli back from suspension and Nenad Krsticic has recovered from injury to bolster their midfield.
Mauro Icardi again takes the centre-forward role with Eder.
The Blucerchiati are out for revenge, as two years ago a defeat in the Derby effectively sent them down to Serie B.
Genoa: Frey; Granqvist, Portanova, Manfredini; Pisano, Kucka, Matuzalem, Antonelli, Moretti; Immobile, Borriello
Sampdoria: Romero; Gastaldello, Palombo, Costa; De Silvestri, Obiang, Krsticic, Poli, Estigarribia; Icardi, Eder