Inter try to end their crisis against Parma in the lunchtime kick-off, but are forced to change yet again due to injuries.
The Nerazzurri aim to prevent a fifth consecutive home defeat in all competition at 11.30am UK time (10.30 GMT). Click here for a match preview.
Andrea Stramaccioni’s absentee list actually increased this week with Esteban Cambiasso and Fredy Guarin missing out.
They join Rodrigo Palacio, Antonio Cassano, Diego Milito, Walter Gargano, Yuto Nagatomo, Ibrahima Mbaye, Gaby Mudingayi, Joel Obi, Dejan Stankovic and Luca Castellazzi.
Once again, Tommaso Rocchi is the only available striker with support from Ricky Alvarez, while Ezequiel Schelotto and Alvaro Pereira take the flanks.
The few remaining players are also tired, having lost 3-2 at home to Roma in the Coppa Italia semi-final on Wednesday evening.
Parma also have a few problems after their 3-0 home defeat to Udinese, as Gabriel Paletta sits out a ban with MacDonald Mariga and Raffaele Palladino sidelined.
Jonathan Biabiany and Fabiano Santacroce were in doubt, but are fit to start, while Marco Parolo returns from suspension.
The Ducali have lost the last six editions of this fixture and won at San Siro only once in May 1999.
Inter: Handanovic; Jonathan, Ranocchia, Juan Jesus, Zanetti; Schelotto, Kovacic, Kuzmanovic, Pereira; Alvarez; Rocchi
Inter bench: Belec, Carrizo, Silvestre, Benassi, Samuel, Chivu, Pasa, Forte, Belloni, Garritano, Ferrara
Parma: Mirante; Benalouane, Coda, Lucarelli, Gobbi; Marchionni, Valdes, Parolo; Sansone, Amauri, Belfodil
Parma bench: Pavarini, Bajza, Ampuero, Morrone, Mesbah, Biabiany, Galloppa, Santacroce, Strasser, Boniperti, Cerri, Rosi