Udinese must win to keep their European hopes alive, while Sampdoria are yet to secure their Serie A safety.
The lunchtime fixture is at the Stadio Friuli at 11.30am UK time (10.30 GMT). Click here for a match preview.
Francesco Guidolin’s men are right back in the thick of the race for Europe after a run of four consecutive victories.
Andrea Lazzari is out of action, but Mathias Ranegie and Alexander Merkel are back in the squad.
Antonio Di Natale starts with support from teenage sensation Piotr Zielinski and Roberto Pereyra.
Sampdoria have hit problems recently and are without a victory in seven rounds. They are only six points clear of the relegation zone, so are starting to feel the heat.
Daniele Gastaldello and captain Angelo Palombo are both suspended, while Andrea Costa and Nenad Krsticic are injured.
It leaves Coach Delio Rossi needing to completely revamp the defence with Shkodran Mustafi and Paolo Castellini.
Mauro Icardi returns to the starting XI with Eder.
Udinese: Brkic; Benatia, Danilo, Domizzi; Basta, Allan, Pinzi, Gabriel Silva; Zielinski, Pereyra; Di Natale
Sampdoria: Romero; Mustafi, Rossini, Castellini; De Silvestri, Renan, Obiang, Poli, Estigarribia; Icardi, Eder