Lazio risk being left behind in the race for Europe and welcome a Bologna side who are unbeaten in five.
Vladimir Petkovic’s side are in crisis, losing five of the last eight games and failing to score in six of them.
Alvaro Gonzalez returns from suspension, but Giuseppe Biava is now banned along with the injured Ederson, Stefano Mauri and Cristian Brocchi.
Miroslav Klose leads the attack with support from Antonio Candreva, Hernanes and Senad Lulic.
Bologna have drawn their last five on the bounce, but are not 100 per cent safe from the threat of relegation yet.
Archimede Morleo sits out a one-match ban, joining the sidelined Gianluca Curci and Niccolo Cherubin, but Manolo Gabbiadini returns.
Surprisingly, 19-year-old Dejan Stojanovic gets his Serie A debut in goal.
Lazio: Marchetti; Konko, Dias, Cana, Radu; Ledesma; Candreva, Floccari, Hernanes, Lulic; Klose
Lazio bench: Bizzarri, Scarfagna, Ciani, Onazi, Crecco, Cataldi, Pereirinha, Stankevicius, Kozak, Gonzalez, Rozzi, Saha
Bologna: Stojanovic; Motta, Sorensen, Antonsson, Abero; Perez, Taider; Gabbiadini, Diamanti, Kone; Gilardino
Bologna bench: Agliardi, Natali, Carvalho, Garics, Naldo, Guarente, Krhin, Pazienza, Riverola, Christodoulopoulos, Pasquato, Moscardelli
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more