This is a Serie A classic and sees second-place Napoli welcome an Inter side in absolute crisis with no strikers at all.
The Partenopei are unbeaten in this fixture since October 1997, earning four wins and two draws.
Walter Mazzarri’s men are feeling confident and welcome Edinson Cavani and Valon Behrami back from suspension.
Goran Pandev faces his former club, while Miguel Angel Britos and Alessandro Gamberini join Paolo Cannavaro in defence.
Inter, on the other hand, are in dire straits thanks to five defeats in the last seven rounds and an epic injury crisis.
Javier Zanetti and Matias Silvestre were the latest additions, joining Diego Milito, Rodrigo Palacio, Antonio Cassano, Walter Gargano, Yuto Nagatomo, Walter Samuel, Dejan Stankovic, Gaby Mudingayi, Joel Obi, Luca Castellazzi and Ibrahima Mbaye.
Esteban Cambiasso and Fredy Guarin are back in the squad, but Andrea Ranocchia and Tommaso Rocchi are carrying knocks.
Ranocchia has a recurring knee problem, but is in the starting XI, while Rocchi’s absence means there are absolutely no available senior squad strikers.
Inter have to improvise with Ricky Alvarez and Guarin starting together up front.
Napoli: 1 De Sanctis; 55 Gamberini, 18 Cannavaro, 5 Britos; 11 Maggio, 85 Behrami, 20 Dzemaili, 18 Zuniga; 17 Hamsik; 19 Pandev, 7 Cavani
Napoli bench: 22 Rosati, 15 Colombo, 2 Grava, 4 Donadel, 6 Rolando, 9 Calaiò, 13 El Kaddouri, 16 Mesto, 24 Insigne, 25 Radosevic, 27 Armero, 88 Inler
Inter: 1 Handanovic; 23 Ranocchia, 26 Chivu, 40 Juan Jesus; 42 Jonathan, 17 Kuzmanovic, 10 Kovacic, 24 Benassi, 31 Pereira; 14 Guarin, 11 Alvarez
Inter bench: 27 Belec, 30 Carrizo, 7 Schelotto, 18 Rocchi, 19 Cambiasso, 28 Pasa, 45 Forte, 61 Garritano, 62 Ferrara, 63 Spendlhofer