Napoli have the opportunity to lock down second place and take revenge on their bête noir Bologna.
The Partenopei have faced Bologna twice this season and lost both at the San Paolo between Serie A and the Coppa Italia.
Hugo Campagnaro is still unavailable due to a calf problem, but other than him Walter Mazzarri has a full squad at his disposal.
Edinson Cavani partners Lorenzo Insigne with support from Marek Hamsik, while Rolando steps into the back three.
Bologna are not quite safe from relegation yet, although they are practically out of that tussle.
Tiberio Guarente sits out a ban with Gianluca Curci, Mikael Antonsson and Niccolò Cherubin injured.
Archimede Morleo returns from suspension to boost the side, who were demolished 6-0 by Lazio on Sunday.
Despite that shocking defeat on his Serie A debut, Dejan Stojanovic is confirmed in goal.
Bologna: Stojanovic; Motta, Sorensen, De Carvalho, Morleo; Taider, Perez; Christodoulopoulos, Diamanti, Kone; Gilardino
Napoli: De Sanctis; Rolando, Cannavaro, Britos; Maggio, Behrami, Dzemaili, Hamsik, Zuniga; Insigne, Cavani