Fiorentina host desperate Palermo in an intriguing lunchtime battle, as both teams are in dire need of points to keep their dreams alive.
It kicks off at the Stadio Artemio Franchi in Florence at 11.30am UK time (10.30 GMT). Click here for a match preview.
The Viola’s hopes of catching Milan in third are looking bleak, but they remain solidly in fourth place.
Adem Ljajic continues his two-match ban for insulting officials, joined by the injured Marcelo Larrondo, Momo Sissoko and Michele Camporese.
Luca Toni therefore partners Stevan Jovetic, facing the club that really put him on the map. Alberto Aquilani is only fit enough for a spot on the bench.
Palermo make the trip without Josip Ilicic, Mauro Boselli, Diego Fabbrini and the suspended Edgar Barreto.
Fabrizio Miccoli left the pitch in floods of tears when losing 3-2 to Udinese on Wednesday night, a result that has all but doomed them to relegation, but is surprisingly on the bench.
If there is to be any hope at all, they must win in Florence and hope Inter can trip up Genoa.
Fiorentina: Viviano; Roncaglia, Rodriguez, Savic; Cuadrado, Fernandez, Pizarro, Borja Valero, Pasqual; Jovetic, Toni
Fiorentina bench: Neto, Hegazi, Compper, El Hamdaoui, Aquilani, Lupatelli, Llama, Migliaccio, Wolski, Tomovic, Rossi, Romulo
Palermo: Sorrentino; Munoz, Donati, Von Bergen; Morganella, Arevalo Rios, Faurlin, Kurtic, Garcia; Dybala, Hernandez
Palermo bench: Benussi, Mantovani, Aronica, Viola, Dossena, Miccoli, Anselmo, Sperduti, Nelson, Brichetto, Formica, Sanseverino
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more