In recent years Lazio-Udinese has always been a battle for Europe and this time they both need to recover from shock defeats.
The last few days have been hard going for these sides, as the Biancocelesti were hammered 4-0 by Juventus in the Italian Super Cup.
Because of racist chanting from a group of fans during that match, the Curva Nord has been closed off for this Serie A opener.
Udinese’s Europa League hopes are hanging by a thread after their 3-1 first leg home play-off defeat to Slovan Liberec on Thursday.
Antonio Di Natale needed five stitches and was diagnosed with mild head trauma following a collision in that game, but is passed fit to start with Maicosuel and Roberto Pereyra.
Zeljko Brkic is still out of action, so Ivan Kelava takes the goalkeeping gloves for Udinese.
Lazio are without Abdoulay Konko, Felipe Anderson, Alfaro, Bruno Pereirinha and Vinicius.
Stefano Mauri is still in the stands, as he is waiting for an appeal verdict against his six-month ban for failing to alert authorities to a potential fix.
Diego Novaretti is a surprise pick in defence, while Lucas Biglia and Hernanes support Miroslav Klose.
Lazio: Marchetti; Cavanda, Novaretti, Cana, Radu; Candreva, Gonzalez, Biglia, Hernanes, Lulic; Klose
Udinese: Kelava; Naldo, Danilo, Domizzi; Basta, Pinzi, Badu, Pasquale; Maicosuel, Pereyra; Di Natale
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more