Rafa Benitez presents his all-new Napoli including Gonzalo Higuain and Pepe Reina, but can he break the Bologna curse?
It kicks off at 19.45 UK time at the Stadio San Paolo, click here for a match preview.
Stefano Pioli has been something of a Bogey Man for the Partenopei, as last season they knocked Napoli out of the Coppa Italia and beat them here in Serie A.
Benitez has opted for Goran Pandev, Marek Hamsik and Jose Maria Callejon to fan out behind former Real Madrid hitman Higuain.
Pablo Armero and Blerim Dzemaili are unavailable due to suspension, but captain Paolo Cannavaro is dropped.
Bologna have to do without Archimede Morleo, Niccolo Cherubin and Frederik Sorensen, while they lost Alberto Gilardino to Genoa this summer.
Alessandro Diamanti will be hoping for another fantastic campaign so he can earn his spot for Italy in the 2014 World Cup.
Ex-Torino and Manchester City striker Rolando Bianchi has arrived to fill the hole left by Gila in the Rossoblu attack.
Napoli: Reina; Maggio, Albiol, Britos, Zuniga; Inler, Behrami; Callejón, Hamsik, Pandev; Higuain
Bologna: Curci; Garics; Antonsson; Natali; Cech; Krhin; Della Rocca; Kone; Diamanti; Christodoulopoulos; Bianchi