Fiorentina reshuffle again with Giuseppe Rossi partnering Mario Gomez away to Genoa, but Juan Cuadrado is rested.
It kicks off at 19.45 UK time (18.45 GMT) at the Stadio Luigi Ferraris, click here for a match preview.
Vincenzo Montella said this week the Viola have more pressure on them than any other club, including two-times Scudetto winners Juventus.
Much is expected of them after bringing in so many impressive names, but on Thursday they squeezed through to the Europa League on away goals after a 1-0 home defeat to Grasshoppers.
Rossi returns to the starting XI to partner Gomez, while Juan Cuadrado is carrying a knock and therefore rested. This prompts a change of system to 4-3-1-2 with Borja Valero in a trequartista role.
Facundo Roncaglia is out of action for the defence, so Marvin Compper gets a rare start.
Genoa need a boost after a dismal start to the season, going out of the Coppa Italia and losing 2-0 at Inter in Serie A.
Alberto Gilardino leads the attack with Antonio Floro Flores and Francesco Lodi pulling the midfield strings.
Luca Antonini is on the bench just 24 hours after his move from Milan.
Genoa: Perin; Antonelli, Portanova, Sampirisi, Manfredini; Santana, Lodi, Kucka, Biondini; Floro Flores, Gilardino
Genoa bench: Donnarumma, Zima, Antonini, De Maio, Gamberini, Kofie, Matuzalem
Fiorentina: Neto; Tomovic, Gonzalo Rodriguez, Compper, Pasqual; Pizarro, Ambrosini, Aquilani; Borja Valero; Rossi, Gomez
Fiorentina bench: Munua, Alonso, Bakic, Cuadrado, Mati Fernandez, Savic, Joaquin, Vecino, Wolski, Matos, Santos, Ryder, Ilicic, Iakovenko