Mirko Vucinic partners Carlos Tevez, while Rodrigo Palacio starts with Ricky Alvarez as Inter host Juventus in the Derby d’Italia.
It’s an unusually early kick-off at San Siro, 17.00 UK time (16.00 GMT). Click here for a match preview.
Unlike last season, this is a top of the table showdown, as both teams have a 100 per cent record after two rounds.
Inter have not conceded a single goal yet with Samir Handanovic putting himself forward as one of the best goalkeepers in Serie A.
Jonathan and Nagatomo are confirmed on the wings, where they have been so impressive in Walter Mazzarri’s 3-5-2 formation.
Alvarez supports Palacio, while Diego Milito is on the bench for the first time since snapping knee ligaments in February.
Saphir Taider gets the nod in midfield ahead of Mateo Kovacic, though Javier Zanetti and Cristian Chivu are still sidelined.
Juventus had several big injury doubts on their hands after international duty last week, but both Vucinic and Andrea Barzagli have been passed fit to start.
The Montenegro striker partners Tevez in his first Derby d’Italia and the Argentine will hope to continue his record of scoring in every competitive game for Juventus so far.
Paul Pogba starts in midfield in place of the injured Claudio Marchisio, joining Andrea Pirlo and Arturo Vidal.
Martin Caceres and Simone Pepe are also unavailable.
Juventus have won their last two visits to Inter by 2-1 scorelines and are unbeaten here since April 2010.
This represents Antonio Conte’s 100th official match on the Bianconeri bench.
Inter: Handanovic; Campagnaro, Ranocchia, Juan Jesus; Jonathan, Guarin, Cambiasso, Taider, Nagatomo; Alvarez, Palacio
Juventus: Buffon; Barzagli, Bonucci, Chiellini; Lichtsteiner, Vidal, Pirlo, Pogba, Asamoah; Tevez, Vucinic