Fiorentina must beat Cagliari to maintain their 100 per cent record and stay top of the table in the lunchtime match.
The Stadio Artemio Franchi hosts the 11.30am UK time kick-off (10.30 GMT). Click here for a preview.
Vincenzo Montella has to do without the injured Josip Ilicic and Stefan Savic, but Giuseppe Rossi has shaken off a knock to partner Mario Gomez.
Captain Manuel Pasqual starts despite needing 50 stitches on a horrific head wound he suffered on international duty with Italy on Tuesday.
David Pizarro is struggling with a back problem, so Massimo Ambrosini steps into midfield.
The Coach stated he could use Juan Cuadrado as a right-back, so the 3-5-2 line-up could mutate to four at the back during the game.
Cagliari were unlucky to lose against Milan in the last round and eager to make their mark in Tuscany this afternoon.
Andrea Cossu is back from injury to join Marco Sau and Victor Ibarbo, but Francesco Pisano and Agim Ibraimi are out.
The Sardinians beat Fiorentina 2-1 when they last met back in March, but Cagliari have not conquered the Stadio Franchi since 1972, followed by four draws and 22 defeats.
To make matters worse, the Rossoblu are without an away victory since February.
Fiorentina: Neto; Tomovic, Rodriguez, Roncaglia; Cuadrado, Aquilani, Borja Valero, Ambrosini, Pasqual; Gomez, Rossi
Fiorentina bench: Munua, Alonso, Commper, Pizarro, Bakic, Rebic, Fernandez, Joaquin, Wolski, Matos, Vargas, Iakovenko
Cagliari: Agazzi; Dessena, Rossettini, Astori, Murru; Perico, Conti, Nainggolan; Cossu; Sau, Ibarbo
Cagliari bench: Avramov, Ariaudo, Avelar, Nenè, Ekdal, Cabrera, Pinilla