Sassuolo are propping up the table, but Coach Eusebio Di Francesco doubts Walter Mazzarri will let Inter get complacent.
The early kick-off is at 11.30am UK time (10.30 GMT) at the Mapei Stadium in Reggio Emilia. Click here for a match preview.
“It will be difficult against Inter and we’ll try to pick up some of the points we’ve dropped along the way so far this season,” said Di Francesco in his Press conference.
“Mazzarri is very good at keeping the tension at the right level, so I’m sure they won’t get distracted by the talk of selling the club or the fact we’re on paper an ‘easy’ mark.”
Sassuolo are in their first ever top flight campaign, but have so far scored just one goal and conceded eight.
“We have improved since the start of the season, even if the result was harsh against Verona last week. The team has balance, we just need to be more efficient in front of goal.
“It is not possible for us to create so many chances against Hellas and not win. We worked on that during the week in training.”
There are some problems for the side, as Emanuele Terranova is out for six months after snapping the anterior cruciate ligament in his right knee.
Domenico Berardi is still suspended, while Gomes, Carl Valeri and Luca Marrone are unavailable.
Sassuolo squad for Inter: Pegolo, Pomini, Rosati, Acerbi, Antei, Bianco, Gazzola, Longhi, Marzorati, Pucino, Rossini, Ziegler, Chibsah, Kurtic, Laribi, Magnanelli, Missiroli, Schelotto, Alexe, Farias, Floro Flores, Masucci, Zaza