The Derby della Capitale has never been so ramped up, as Roma defend their 100 per cent record and want revenge on Lazio.
It kicks off at the Stadio Olimpico at 14.00 UK time (13.00 GMT), click here for the match preview.
When these sides last met in May, Lazio won 1-0 with a Senad Lulic goal to decide the Coppa Italia Final and book their spot in the Europa League at the expense of Roma.
The whole summer has been dominated by that match and the repercussions, so the Giallorossi know they have a point to prove.
Francesco Totti also celebrates having extended his contract this week, completing the trident with Alessandro Florenzi and Gervinho.
Michael Bradley and Mattia Destro are out of action, but there’s a classy midfield with Daniele De Rossi, Kevin Strootman and Miralem Pjanic.
Lazio’s fortunes have been a little shaken since the Coppa Italia Final, as they lost the Italian Super Cup 4-0 to Juventus and fans protested at a disappointing transfer campaign.
Lucas Biglia was their main buy and he’s out injured for the Derby, joining Stefan Radu, Giuseppe Biava, Bruno Pereirinha and the suspended Stefano Mauri.
Miroslav Klose leads the way with support from Hernanes, Antonio Candreva and Coppa Italia hero Lulic.
Roma: De Sanctis; Maicon, Benatia, Castan, Balzaretti; Pjanic, De Rossi, Strootman; Florenzi, Totti, Gervinho
Lazio: Marchetti; Cavanda, Ciani, Cana, Konko; Ledesma; Candreva, Gonzalez, Hernanes, Lulic; Klose
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £5,000 monthly.