Inter aim to continue their unbeaten run by taking on Cagliari, but Walter Mazzarri is forced into changes.
The Stadio Nereo Rocco in Trieste hosts this game, as the Sant’Elia reconstruction work has not been completed. It kicks off at 14.00 UK time (13.00 GMT), click here for a match preview.
This venue was also at risk, as there was a heavy thunderstorm over Trieste this morning and the pitch is affected.
Mazzarri has until now used basically the same starting XI for every round, but is forced into changes because they only played against Fiorentina on Thursday evening.
Jonathan, Saphir Taider and Hugo Campagnaro are rested in favour of Alvaro Pereira, Mateo Kovacic and Rolando.
Cagliari are also revamped in midfield, as Albin Ekdal and Andrea Cossu are injured, so Matias Cabrera is the trequartista behind Mauricio Pinilla and Victor Ibarbo.
Cagliari: Agazzi; Perico, Rossettini, Astori, Murru; Dessena, Conti, Nainggolan; Cabrera; Pinilla, Ibarbo
Inter: Handanovic; Rolando, Ranocchia, Juan Jesus; Nagatomo, Guarin, Cambiasso, Kovacic, Pereira; Alvarez, Belfodil