Roma aim to add another chapter to the history books as they host Bologna looking for a sixth straight victory.
The Stadio Olimpico lights up for the Serie A leaders at 19.45 UK time (18.45 GMT), click here for a match preview.
Rudi Garcia has already set a new record, as Roma had never before won their opening five rounds of the campaign.
They are the only side left with a perfect run and hope to maintain that, although Douglas Maicon joined Michael Bradley and Mattia Destro on the absentee list.
Francesco Totti starts just two days after celebrating his 37th birthday, partnering Gervinho and Alessandro Florenzi.
Vasilis Torosidis steps in at right-back for the injured Maicon.
Bologna are still without a win this season and are smarting after fumbling a 3-1 lead in the final minutes to draw 3-3 with Milan on Wednesday night.
Niccolo Cherubin, Frederik Sorensen and the suspended Cesare Natali are unavailable for Coach Stefano Pioli.
Alessandro Diamanti is joined by Panagiotis Kone and Diego Laxalt – who bagged a brace against Milan midweek – fanning out behind Jonatan Cristaldo.
The Rossoblu won here 3-2 and are unbeaten in their last three visits to the Olimpico, so could cause an upset.
Roma: De Sanctis; Torosidis, Benatia, Castan, Balzaretti; Pjanic, De Rossi, Strootman; Florenzi, Totti, Gervinho
Roma bench: Lobont, Skorupski, Dodò, Burdisso, Jedvaj, Romagnoli, Taddei, Marquinho, Ricci, Caprari, Borriello, Ljajic
Bologna: Curci; Garics, Antonsson, Mantovani, Morleo; Pazienza, Perez; Kone, Diamanti, Laxalt; Cristaldo
Bologna bench: Stojanovic, Agliardi, Radakovic, Cech, Crespo, Krhin, Della Rocca, Christodoulopoulos, Gimenez, Acquafresca, Bianchi, Moscardelli
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!