Mario Balotelli, Riccardo Montolivo and Robinho start as Milan visit Ajax in the Champions League.
The Rossoneri are currently joint top of Group H after beating Celtic 2-0 in their opener, while the Dutch giants lost 4-0 at Barcelona.
Bojan Krkic is unable to face his former teammates, as the on-loan Barca boy is out with a hamstring injury.
Ajax’s confidence was boosted on Saturday by a 6-0 domestic victory over Go Ahead Eagles.
Milan have Balotelli available, as his three-match ban for insulting the referee only applies to Serie A, while Montolivo returns from injury.
However, Stephan El Shaarawy misses out again along with Kaka, Daniele Bonera, Riccardo Saponara, Matias Silvestre, Giampaolo Pazzini, Mattia De Sciglio and Daniele Bonera.
There was a last-minute change when Valter Birsa pulled out in the warm-up, so Andrea Poli came in and pushed Riccardo Montolivo to a more advanced role.
Ajax have not beaten any Italian clubs in Amsterdam since a 2-1 victory over Roma in the 2002-03 Champions League.
Ajax: Cillessen; Van Rhijn, Moisander, Denswil, Blind; S De Jong, C Poulsen, Duarte; De Sa, Sigthorsson, Fischer
Ajax bench: Vermeer, Van Der Hoorn, Boilesen, Schone, Andersen, Klaassen, Hoesen
Milan: Abbiati; Abate, Mexes, Zapata, Constant; Poli, De Jong, Muntari; Montolivo, Robinho; Balotelli
Milan bench: Amelia, Zaccardo, Poli, Nocerino, Cristante, Emanuelson, Matri