The two dark horses for the Scudetto go head-to-head at San Siro tonight, while Sunday brings Juventus-Milan and Lazio-Fiorentina.
The action starts today at 17.00 UK time (16.00 GMT) with Chievo-Atalanta a relegation six-pointer.
Tonight Rudi Garcia’s Roma defend their perfect record against a revived Inter.
On Sunday the early kick-off is Parma-Sassuolo, followed by Napoli-Livorno and a late double-header.
Juventus and Milan both have a point to prove in Turin and Lazio-Fiorentina is sure to be an intriguing battle for Europe.