Gian Piero Gasperini makes his comeback on the Genoa bench and adopts a 3-4-3 in the difficult trip to Catania.
It kicks off at the Stadio Massimino at 14.00 UK time (13.00 GMT), click here for a match preview.
This is an emotional moment for several members of the Grifone party, as Francesco Lodi also returns to face his former teammates and fans in Sicily.
Gasperini was brought in this week to replace sacked Coach Fabio Liverani, his return to the club three years after being sacked.
Luca Antonelli is still sidelined, but Gasp switches to his beloved 3-4-3 system with Alberto Gilardino, Juraj Kucka and Mario Alberto Santana.
Catania took off some of the pressure last week when earning their first win of the season, beating Chievo 2-0.
Nicolas Spolli missed out with injury, but Pablo Alvarez and Giuseppe Bellusci returned to the squad.
Catania: Andujar; Alvarez, Bellusci, Legrottaglie, Biraghi; Tachtsidis, Plasil, Almiron; Castro Bergessio, Barrientos
Genoa: Perin; Antonini, Portanova, Manfredini; Vrsaljko, Matuzalem, Lodi, Sampirisi; Kucka, Gilardino, Santana