Tonight the Stadio Olimpico lights up for a huge top of the table showdown between Roma and Napoli, but Gonzalo Higuain is dropped.
Only two points separate these teams, as the Giallorossi have a 100 per cent record after seven rounds.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
Francesco Totti shook off a minor injury to start with Gervinho and Alessandro Florenzi, leaving Adem Ljajic on the bench.
Federico Balzaretti is suspended and replaced by Dodo, while Douglas Maicon returns from his lay-off at right-back.
It is a very special game for Roma goalkeeper Morgan De Sanctis, who faces his former club for the first time.
Napoli were due to welcome back Higuain following his injury problems, but the thigh muscle is still not at 100 per cent and it's reported the Argentine asked not to be used from the start.
Instead, ex-Lazio striker Goran Pandev goes into the centre-forward role supported by Marek Hamsik, Jose Maria Callejon and Lorenzo Insigne.
Giandomenico Mesto gives Pablo Armero a rest at left-back due to jet-lag.
Christian Maggio also returns after a month out, but Juan Camilo Zuniga will undergo keyhole knee surgery on Monday.
Napoli legend Diego Armando Maradona is expected to be in the stands for this big match.
Roma: De Sanctis; Maicon, Benatia, Castan, Dodò; Pjanic, De Rossi, Strootman; Florenzi, Totti, Gervinho
Roma bench: Skorupski, Lobont, Torosidis, Burdisso, Romagnoli, Marquinho,Taddei, Bradley, Ricci, Caprari, Ljajic, Borriello
Napoli: Reina; Maggio, Albiol, Britos, Mesto; Inler, Behrami; Callejon, Hamsik, Insigne; Pandev
Napoli bench: Rafael, Armero, Cannavaro, Colombo, Dzemaili, Fernandez, Radosevic, Zapata, Higuain, Mertens