Milan host furious Fiorentina, as Mario Balotelli and Kaka face Giuseppe Rossi and Massimo Ambrosini.
It kicks off at San Siro at 19.45 GMT, click here for a match preview.
The pressure continues to pile on Milan boss Massimiliano Allegri, as a midweek 1-1 draw with Lazio left them in 10th place.
The Viola are currently sixth, but are powered by rage after the controversial 2-1 home defeat to Napoli.
Not only was Juan Cuadrado denied a last-minute penalty, but he was also given a second yellow card for simulation.
Even with video evidence proving he was fouled, the current rules do not allow that ban to be overturned on appeal, so the Colombian is suspended against Milan.
Vincenzo Montella is also without David Pizarro, Mario Gomez and Josip Ilicic, while Ambrosini recovered in time to face his former teammates.
In Cuadrado’s absence, Juan Manuel Vargas steps into the trident with Serie A top scorer Rossi and Ryder Matos.
Philippe Mexes completes his four-match ban for Milan, while Matias Silvestre, Mattia De Sciglio, Daniele Bonera, Stephan El Shaarawy and Giampaolo Pazzini are sidelined.
Balotelli starts with support from Kaka and Valter Birsa, while ex-Fiorentina captain Riccardo Montolivo takes on his old club.
Last season Fiorentina conquered San Siro 3-1, but lost out on third place in controversial circumstances.
Milan: Gabriel; Abate, Zaccardo, Zapata, Constant; Montolivo, De Jong, Muntari; Kaka, Balotelli, Birsa
Milan bench: Amelia, Abbiati, Robinho, Saponara, Matri, Poli, Cristante, Emanuelson, Vergara, Niang
Fiorentina: Neto; Tomovic, Savic, Rodriguez, Pasqual; Aquilani, Borja Valero, Ambrosini; Matos, Rossi, Vargas
Fiorentina bench: Lupatelli, Munua, Alonso, Roncaglia, Compper, Rebic, Joaquin, Vecino, Wolski, Iakovenko, Olivera