Inter aim to become only the second team in over a year to conquer the Stadio Friuli as they visit Udinese.
It kicks off at 14.00 GMT, click here for a match preview.
Walter Mazzarri has to do without Mauro Icardi, Diego Milito, Hugo Campagnaro, Cristian Chivu and the suspended Ishak Belfodil.
Fredy Guarin therefore supports the only available striker, Rodrigo Palacio, pushing Ricky Alvarez into a deeper role.
Andrea Ranocchia comes back into the defence to rest Rolando.
Samir Handanovic has recovered from a knock to the hip in order to face his former club.
The best news for Inter and football in general is that Javier Zanetti has a spot on the bench for the first time since rupturing his Achilles tendon in April.
Udinese had been unbeaten on home turf in 22 Serie A games before Roma snatched a late 1-0 victory last week.
Francesco Guidolin’s men will be particularly eager not to get it wrong again and have Luis Muriel partnering Antonio Di Natale.
Maicosuel and the suspended Giampiero Pinzi are unavailable.
Udinese: Brkic, Naldo, Danilo, Domizzi; Widner, Badu, Allan, Pereryra, Gabriel Silva; Muriel, Di Natale
Udinese bench: Kelava, Benussi, Bubnjic, Ranegie, Milnar, Nico Llopez, Jadson, Lazzari, Bruno Fernandez, Merkel, Heurtaux, Zielinski
Inter: Handanovic; Ranocchia, Samuel, Juan Jesus; Jonathan, Taider, Cambiasso, Alvarez, Nagatomo; Guarin; Palacio
Inter bench: Carrizo, Castellazzi, Zanetti, Andreolli, Kovacic, Mudingayi, Kuzmanovic, Wallace, Puscas, Pereira, Rolando