Lazio are forced to reshuffle again when welcoming Gian Piero Gasperini’s Genoa.
It kicks off at the Stadio Olimpico in Rome at 14.00 GMT, click here for a match preview.
Vladimir Petkovic took some of the heat off with a win over Cagliari and draw at Milan, but the pressure was still on and so was the injury crisis.
He went into this game without Lucas Biglia, Senad Lulic, Andre Dias, Giuseppe Biava, Diego Novaretti, Abdoulay Konko and the banned Lorik Cana and Stefano Mauri.
Miroslav Klose’s return has been crucial and he starts flanked by Antonio Candreva and Felipe Anderson.
Hernanes is not even on the bench, fuelling reports of massive problems within the locker room.
Genoa have been doing considerably better since Gian Piero Gasperini replaced Fabio Liverani, an ex-Lazio player, on the bench.
The new boss picked up seven points from four games, losing only to Juventus in Turin.
Francesco Lodi was a late addition to the injury list, joining Alessandro Gamberini, Emanuele Calaiò, Mario Alberto Santana and Sime Vrsaljko.
Alberto Gilardino as always leads the way with Luca Antonelli in support.
Lazio: Marchetti; Cavanda, Ciani, Radu, Pereirinha; Onazi, Ledesma, Gonzalez; Candreva, Klose, Felipe Anderson
Lazio bench: Berisha, Strakosha, Elez, Pereirinha, Ederson, Floccari, Perea, Keita
Genoa: Perin; Antonini, Portanova, Manfredini; Biondini, Kucka, Matuzalem, Cofie, Marchese; Antonelli; Gilardino
Genoa bench: Bizzarri, Donnarumma, Tozser, Sampirisi, De Maio, Sturaro, Centurion, Bertolacci, Fetfatzidis, Konate, Stoian