Roma lost their perfect record, but can still make it six out of six on home turf against plucky Sassuolo.
It kicks off at the Stadio Olimpico at 14.00 GMT, click here for a match preview.
The Giallorossi are still top of the table, though the record-breaking run of 11 opening victories came to a halt with a 1-1 at Torino.
Francesco Totti and Mattia Destro are still out injured, but Gervinho returns from his lay-off for a place on the bench.
Mehdi Benatia is suspended, but Leandro Castan’s ban has expired, so Nicolas Burdisso remains at centre-back.
There’s a more attacking trident than usual, as Marco Borriello and Adem Ljajic start together with Alessandro Florenzi, returning Miralem Pjanic to midfield.
Sassuolo are in their first ever Serie A season and last week earned a thrilling 4-3 victory at Sampdoria.
Simone Zaza returns from suspension for a spot on the bench and Domenico Berardi is definitely one to watch, as the 19-year-old bagged a hat-trick at Marassi.
Emanuele Terranova and Gomes are unavailable for Coach Eusebio Di Francesco, who won the Scudetto at Roma in 2001.
Roma: De Sanctis, Maicon, Burdisso, Castan, Balzaretti, De Rossi, Pjanic, Strootman, Florenzi, Borriello, Ljajic
Roma bench: Lobont, Skorupski, Torosidis, Jedvaj, Romagnoli, Dodò, Taddei, Marquinho, Bradley, Ricci, Caprari, Gervinho
Sassuolo: Pegolo; Antei, Bianco, Acerbi; Gazzola, Marrone, Magnanelli, Longhi; Berardi, Floro Flores, Missiroli
Sassuolo bench: Pomini, Rosati, Rossini, Ziegler, Schelotto, Kurtic, Chibsah, Laribi, Alexe, Masucci, Farias, Zaza