Lazio want to shake off some of the pressure with a result against Parma, as Antonio Cassano faces Miroslav Klose.
It kicks off at the Stadio Tardini at 14.00 GMT, click here for a match preview.
Vladimir Petkovic was still feeling the tension after a 2-0 home defeat to Genoa, while Thursday’s 2-1 victory over Apollon Limassol was far from convincing.
Michael Ciani is suspended with Andre Dias, Senad Lulic and Giuseppe Biava injured, so the defence has to be completely reshuffled.
Klose returns to lead the attack, flanked by Antonio Candreva and Keita Balde.
Parma suffered a rare home defeat against Juventus last week, though Paul Pogba’s goal was offside.
Walter Gargano is away on international duty for Uruguay, while Daniele Galloppa, Stefano Okaka and Nicola Pavarini are injured.
Amauri is still trying to find his form, so is left on the bench, as Raffaele Palladino, Cassano and surprise top scorer Marco Parolo start.
Lazio haven’t conquered the Stadio Tardini since the 2009-10 campaign.
Parma: Mirante; Cassani, Lucarelli, Felipe; Rosi, Obi, Marchionni, Parolo, Gobbi; Palladino, Cassano
Parma bench: Bajza, Coric, Benalouane, Paletta, Mendes, Mesbah, Biabiany, Munari, Acquah, Valdes, Amauri, Sansone
Lazio: Marchetti; Pereirinha, Novaretti, Cana, Radu; Onazi, Ledesma, Hernanes; Candreva, Klose, Keita
Lazio bench: Berisha, Guerrieri, Vinicius, Konko, Cavanda, Elez, Biglia, Felipe Anderson, Perea, Floccari