Juventus can temporarily go top of the table with a win away to Livorno, but are forced to play Arturo Vidal at centre-back.
It kicks off at the Stadio Armando Picchi at 14.00 GMT, click here for a match preview.
As Roma don’t play Cagliari until Monday evening, the Bianconeri are just one point off the leaders and could spend at least 24 hours in the top spot.
However, Antonio Conte has to deal with a large number of absentees, most of them centred around the defence.
Leonardo Bonucci and Angelo Ogbonna are both suspended, while Andrea Barzagli, Mauricio Isla, Stephan Lichtsteiner, Sebastian Giovinco and Simone Pepe are injured.
This forces a radical reshuffle of the back line with Vidal re-routed to centre-back with Martin Caceres and Livorno-born Giorgio Chiellini.
It’s not the first time the Chilean midfielder has been used in defence, as he already played there in 2012 against Genoa and Fiorentina.
In attack, Fernando Llorente is again used as the partner for Carlos Tevez. This is a very special game for Gianluigi Buffon, his 500th Serie A appearance.
Livorno are hovering just above the relegation zone and haven’t beaten Juventus in Tuscany since a 1-0 result in 1940-41.
The Amaranto are also missing star players, as top scorer Paulinho sits out a ban.
Innocent Emeghara therefore partners Luca Siligardi, as the two have so far been taking turns at starting alongside Paulinho.
Livorno: Bardi; Coda, Rinaudo, Ceccherini; Schiattarella, Luci, Mbaye, Emerson, Greco; Siligardi, Emeghara
Livorno bench: Aldegani, Anania, Lambrughi, Piccini, Gemiti, Biagianti, Valentini, Belinghieri, Decarli, Mosquera, Benassi, Borja
Juventus: Buffon; Caceres, Vidal, Chiellini; Padoin, Pogba, Pirlo, Marchisio, Asamoah; Tevez, Llorente
Juventus bench: Storari, Rubinho, De Ceglie, Peluso, Motta, Quagliarella, Vucinic