Milan are forced into a completely revamped defence for the early kick-off away to Maxi Lopez’s Catania.
It begins at 11.30 GMT, click here for a match preview.
The Rossoneri ended their crisis of results in the Champions League when thrashing Celtic 3-0 on Tuesday, but are still floundering in Serie A with three points from the last five rounds.
This week the club was also in chaos, as yesterday President Silvio Berlusconi rejected Adriano Galliani’s resignation, instead making him a joint CEO with Barbara Berlusconi.
Coach Max Allegri has an injury crisis to deal with, as Christian Abbiati, Philippe Mexes, Ignazio Abate, Mattia De Sciglio, Cristian Zaccardo, Marco Amelia, Giampaolo Pazzini and Robinho are out of action.
With Cristian Zapata also suspended, they are forced to use midfielder Andrea Poli as a makeshift right-back and youngster Gabriel in goal.
Mario Balotelli is supported by Kaka and Valter Birsa in the new Christmas Tree formation that proved effective against Celtic.
Catania aren’t in much better shape, as they are rock bottom of the table and lost 4-1 at Torino last week.
Gonzalo Bergessio, Giuseppe Bellusci, Mariano Izco, Sergio Almiron and Milan-owned Kinglsey Boateng are unavailable.
Another former Rossoneri player, Maxi Lopez, leads the line with ex-Roma man Panagiotis Tachtsidis in midfield.
Catania: Andujar; Peruzzi, Spolli, Rolin, Biraghi; Plasil, Tachtsidis, Monzon; Barrientos, Maxi Lopez, Castro
Catania bench: Ficara, Frison, Alvarez, Cabalceta, Capuano, Gyomber, Keko, Legrottaglie, Freire, Guarente, Leto, Petkovic
Milan: Gabriel; Poli, Bonera, Silvestre, Emanuelson; Montolivo, De Jong, Nocerino; Birsa, Kaka; Balotelli
Milan bench: Coppola, Ferrari, Constant, Vergara, Cristante, Saponara, El Shaarawy, Matri, Niang