Javier Zanetti gets his first start of the season as Inter host Sinisa Mihajlovic’s Sampdoria with Erick Thohir in the stands.
It kicks off at 14.00 GMT at San Siro, click here for the match preview.
This will be the first game with President Thohir at the Stadio Giuseppe Meazza and before kick-off there will be a parade of 54 former Nerazzurri stars, including Luis Figo and Dejan Stankovic.
Walter Mazzarri could do with a few of them, as he is without Yuto Nagatomo, Mauro Icardi, Diego Milito, Zdravko Kuzmanovic, Walter Samuel and Cristian Chivu.
Rodrigo Palacio is again joined by Fredy Guarin in a more advanced role, but the big news is that Zanetti has his first start since rupturing his Achilles tendon.
Rolando is picked instead of Andrea Ranocchia in the back three.
It is a very special moment for Mihajlovic, who called Inter home both as a player and assistant manager under Roberto Mancini.
He made his debut on the Samp bench last week, held by a 94th-minute Lazio equaliser despite the Blucerchiati being down to 10 men.
Nenad Krsticic is suspended for this trip, so ex-Inter midfielder Angelo Palombo starts in midfield.
Eder returns from his ban to partner Manolo Gabbiadini, Nicola Pozzi and Roberto Soriano.
Inter: Handanovic; Campagnaro, Rolando, Juan Jesus; Jonathan, Taider, Cambiasso, Alvarez, Zanetti; Guarin; Palacio
Inter bench: Carrizo, Castellazzi, Andreolli, Belfodil, Kovacic, Mudingayi, Wallace, Ranocchia, Puscas, Pereira, Donkor, Olsen
Sampdoria: Da Costa; De Silvestri, Gastaldello, Mustafi, Costa; Palombo, Obiang; Gabbiadini, Eder, Soriano; Pozzi
Sampdoria bench: Fiorillo, Renan, Rodriguez, Castellini, Sansone, Wszolek, Regini, Bjarnason, Maresca, Eramo, Petagna, Fornasier