Massimiliano Allegri visits his hometown club Livorno with Milan, while Napoli host Udinese ahead of Roma-Fiorentina and Inter-Parma.
The action begins at 17.00 GMT when Milan visit Livorno on Allegri’s 100th match for the club, while this evening Napoli welcome Udinese to the San Paolo.
On Sunday the early kick-off at 11.30 GMT is sure to be an electric clash between Roma and Fiorentina, as Adem Ljajic faces his old teammates.
Lazio try to avoid another setback at Torino, while Verona-Atalanta, Sassuolo-Chievo, Cagliari-Genoa and Sampdoria-Catania complete the afternoon schedule.
On Sunday evening Inter host Antonio Cassano’s giant-killing Parma at San Siro.