Napoli rotate their squad with Anthony Reveillere and Rafael getting their debuts against a reshuffled Udinese.
It kicks off at 19.45 GMT at the Stadio San Paolo, click here for the match preview.
Rafa Benitez makes several changes to his line-up, as the Partenopei face a decisive Champions League clash with Arsenal on Wednesday.
Marek Hamsik, Juan Camilo Zuniga and Giandomenico Mesto are all injured, while Miguel Angel Britos sits out a ban.
Goalkeeper Pepe Reina is carrying a knock, so just in case he is rested in favour of 23-year-old Brazilian shot-stopper Rafael on his Serie A debut.
He arrived from Santos in July, but has never actually played a competitive game for the club.
Reveillere, the 34-year-old French defender who was signed on a free transfer last month, is also thrown into the starting XI.
Udinese are forced into changes, as Antonio Di Natale, Luis Muriel and Matias Ranegie are all unavailable due to injury.
Roma-owned Uruguayan talent Nico Lopez therefore gets a rare start in attack with Roberto Pereyra and Bruno Fernandes.
Napoli: Rafael; Maggio, Fernandez, Albiol, Reveillere; Dzemaili, Inler; Insigne, Pandev, Callejon; Higuain
Udinese: Brkic; Heurtaux, Danilo, Domizzi; Basta, Allan, Lazzari, Gabriel Silva; Pereyra, Fernandes; Nico Lopez
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