Juventus need at least a point in Istanbul against Galatasaray to stay in the Champions League, so count on Arturo Vidal against Wesley Sneijder.
It kicks off at 19.45 GMT and will decide the team that goes through along with Real Madrid in Group B. Light snow is expected over the Ali Sami Yen Spoor Kompleksi.
The Bianconeri have stuttered in Europe so far this season, earning just one victory, and were held to a 2-2 draw by Galatasaray on Roberto Mancini’s debut in Turin.
The Italian Coach had taken over from sacked Fatih Terim only two days beforehand.
He can count on Didier Drogba and Fernando Muslera, who is back after breaking his toe over a month ago.
Ex-Inter midfielder Wesley Sneijder has been out of action for six weeks with a thigh strain, but is thrown straight into the starting XI.
Gokhan Zan is introduced to the new-look three-man defence as the player who will challenge Fernando Llorente in the air.
Juve must do without the injured Andrea Pirlo, while Mirko Vucinic is still not 100 per cent fit due to a recurring knee problem.
Carlos Tevez and Fernando Llorente start in attack, supported by Arturo Vidal, Paul Pogba and Claudio Marchisio.
The Bianconeri are unstoppable in Serie A at the moment, notching up seven straight victories without conceding a goal.
Juve’s record in Istanbul is not reassuring, as they have managed a 1-1 draw in December 1998 and lost 2-0 in December 2003.
The only Italian club to beat Galatasaray on home turf was Milan with a 3-1 result back in 1963, followed by three draws and six defeats.
Galatasaray: Muslera; Chedjou, Semih Kaya, Gokhan Zan; Eboue, Felipe Melo, Selcuk Inan, Riera; Sneijder; Drogba, Burak Yilmaz
Galatasaray bench: Ufuk Ceylan, Nounkeu, Ceyhun Gulselam, Bruma, Yekta Kurtulus, Emre Colak, Umut Bulut
Juventus: Buffon; Barzagli, Bonucci, Chiellini; Lichtsteiner, Vidal, Pogba, Marchisio, Asamoah; Tevez, Llorente
Juventus bench: Storari, Caceres, Ogbonna, Isla, Padoin, Quagliarella, Giovinco