Walter Mazzarri and Rafa Benitez face their past in Napoli-Inter, while Juventus-Sassuolo is moved and Milan-Roma concludes on Monday.
There is only one Saturday game, as Juve-Sassuolo was shuffled over to Sunday at 17.30 GMT after their chaotic Champions League experience in Istanbul.
Tonight at 19.45 GMT Hellas Verona aim to shake off recent slip-ups with their visit to bottom of the table Catania.
Sunday afternoon has a series of intriguing ties, including the always very fiery Lazio-Livorno, Fiorentina-Bologna and Udinese-Torino.
There is also a battle of the teams that rose from the dead under new Coaches, as Eugenio Corini’s Chievo welcome Sinisa Mihajlovic’s revamped Sampdoria.
After Juve-Sassuolo, it’s a huge Napoli-Inter clash at the San Paolo to stay in the Scudetto race and above all a blast from the past.
Mazzarri and Benitez each face their former clubs, while Napoli have to shake off their bitter Champions League exit.
Week 16 concludes on Monday evening when Milan host still-unbeaten Roma with Francesco Totti due for his comeback. Can the captain lead the Giallorossi to glory at San Siro?