Walter Mazzarri and Rafa Benitez face their past with a huge title clash between Napoli and Inter at the San Paolo.
It kicks off at 19.45 GMT, click here for a match preview.
Both Coaches are taking on their old clubs, as are several players including Hugo Campagnaro and Goran Pandev.
The Partenopei are still in shock after Wednesday’s Champions League exit, when beating Arsenal 2-0 and earning 12 points was still not enough to keep them in the tournament.
To go out on goal difference in head-to-head records was a heavy blow and they’ll want to pour all that anger into tonight’s Serie A game.
Pepe Reina is still not fit to start after muscular problems, missing his third match in a row, while Valon Behrami, Marek Hamsik, Juan Camilo Zuniga and Giandomenico Mesto are injured.
Gonzalo Higuain is aided by Dries Mertens, Jose Maria Callejon and Lorenzo Insigne in a bid to make the most of Inter’s often slow back three.
Anthony Reveillere gets a rare start after joining mid-season on a free transfer.
Inter are unbeaten in seven official games, but have drawn their last three in the League, including last week’s crazy 3-3 with Parma.
Rodrigo Palacio again leads the way with support from Ricky Alvarez and Fredy Guarin, while Yuto Nagatomo is now fit enough to start on the left.
Mauro Icardi is back on the bench after a long lay-off, but Diego Milito, Walter Samuel and Cristian Chivu are still unavailable.
Inter have not conquered the Stadio San Paolo in all competition since October 1997, picking up only three draws and six defeats.
The Nerazzurri are unbeaten on their travels this season and their last defeat away from home was in Naples on May 5, falling 3-1.
Napoli: Rafael; Maggio, Fernandez, Albiol, Reveillere; Inler, Dzemaili; Insigne, Callejón, Mertens; Higuain
Napoli bench: Colombo, Reina, Uvini, Britos, Bariti, Pandev, Radosevic, Armero, Cannavaro, Behrami, Zapata
Inter: Handanovic; Campagnaro, Ranocchia, Rolando; Jonathan, Taider, Cambiasso, Alvarez, Nagatomo; Guarin; Palacio
Inter bench: Castellazzi, Carrizo, Zanetti, Juan Jesus, Andreolli, Belfodil, Icardi, Kovacic, Mudingayi, Kuzmanovic, Wallace, Pereira
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!