The final Serie A fixture of 2013 is the massive Inter-Milan, but first Juventus, Fiorentina and Lazio face tricky away games and Roma host Catania.
Click here for match previews of every single Serie A Week 17 game, plus reports from Saturday’s Livorno-Udinese and Cagliari-Napoli.
The action begins at 11.30 GMT with under-fire Bologna hosting Genoa in what could be Stefano Pioli’s final outing.
Leaders Juventus travel to Atalanta this afternoon, while Roma host Catania, Fiorentina visit temperamental Sassuolo and Verona try to bring Lazio back down to earth.
Torino-Chievo and Sampdoria-Parma are also intriguing relegation tussles.
At 19.45 GMT the year in Serie A comes to a close with the Derby della Madonnina.