Juventus seek an 11th consecutive victory, but face a Cagliari side who are unbeaten in seven rounds.
It kicks off in Sardinia at 14.00 GMT, click here for a match preview.
Only 5,000 fans will be allowed into the Stadio Sant’Elia, as the venue is undergoing restructuring work.
Antonio Conte’s men are already Winter Champions and eight points clear at the top of the Serie A table after thumping nearest rivals Roma 3-0.
They’ve won their last 10 rounds and are seeking a club record 11th, but Cagliari are without defeat in seven Serie A games.
Andrea Barzagli sits out a ban and is replaced in the back three by Martin Caceres, while Carlos Tevez is again partnered by Fernando Llorente.
Cagliari sold star midfielder Radja Nainggolan to Roma this week and have Nene, Sebastian Eriksson and Michael Agazzi out of action.
Cagliari: Adan; Pisano, Rossettini, Astori, Murru; Dessena, Conti, Ekdal; Cossu; Pinilla, Sau
Juventus: Buffon; Caceres, Bonucci, Chiellini; Lichtsteiner, Vidal, Pirlo, Pogba, Asamoah; Tevez, Llorente
Juventus bench: Storari, Rubinho, Ogbonna, Peluso, Pepe, Padoin, Marchisio, Vucinic, Giovinco, Quagliarella