Juventus aim for a 12th consecutive Serie A victory, but welcome Sinisa Mihajlovic’s fired-up Sampdoria.
It kicks off in Turin at 19.45 GMT, click here for a match preview.
Antonio Conte’s men have already set a club record with 11 straight wins, but aim to keep that run going as long as they can.
Andrea Barzagli returns from suspension to give the Coach a complete squad to choose from, but Conte must also consider Tuesday’s Coppa Italia quarter-final against Roma.
With that in mind, Andrea Pirlo and Leonardo Bonucci are rested in favour of Claudio Marchisio, who is a transfer target for Manchester United, and Angelo Ogbonna.
There are some reports Bonucci is suffering from a slight thigh problem, though it remains to be seen what that means for the Coppa Italia tie.
Carlos Tevez and Fernando Llorente again lead the way in attack. When these sides met in Week 1, Tevez was on target with his debut Serie A strike to give Juve the three points. Paolo Castellini was sent off in stoppages for a crunching tackle on Stephan Lichtsteiner.
Sampdoria earned a shock 2-1 victory here last season with Mauro Icardi’s brace, but he has since moved on to Inter.
Coach Mihajlovic is without the suspended Roberto Soriano and Nenad Krsticic, but are fresh from a 3-0 triumph over Udinese.
The Blucerchiati have lost only two official games since Mihajlovic replaced Delio Rossi, one in Serie A and the other the Coppa Italia.
Pedro Obiang returns from his ban and Eder has support from Manolo Gabbiadini.
Juventus: Buffon; Barzagli, Ogbonna, Chiellini; Lichtsteiner, Vidal, Marchisio, Pogba, Asamoah; Tevez, Llorente
Sampdoria: Da Costa; De Silvestri, Mustafi, Gastaldello, Regini; Palombo, Obiang; Gabbiadini, Bjarnason, Wszolek; Eder