Napoli need a victory to keep up with the top two against Alessandro Diamanti’s Bologna.
It kicks off at 14.00 GMT, click here for a match preview.
Both Juventus and Roma won on Saturday, so the pressure is on the Partenopei to maintain the Scudetto pace.
Marek Hamsik is still not back in the starting XI after nearly two months out injured, but Pepe Reina, Giandomenico Mesto, Valon Behrami and Juan Camilo Zuniga are unavailable.
Gonzalo Higuain leads the attack with support from Dries Mertens, Goran Pandev and Jose Callejon, while January signing Anthony Reveillere takes left-back.
They also played midweek, earning a chaotic 3-1 Coppa Italia win over Atalanta.
Bologna are in dire straits, as new Coach Davide Ballardini only stemmed the crisis by holding Lazio to a 0-0 draw on his debut last week.
Diamanti is the key creative figure in this side and will aim to test Rafael with some of his trademark dipping free kicks.
Rolando Bianchi is his strike partner with Diego Perez and Panagiotis Kone in midfield, but Marek Cech is sidelined.
Bologna have lost their last two meetings with Napoli by a 3-0 result, home and away, with Hamsik scoring three of the goals.
Bologna: Curci; Antonsson, Natali, Cherubin; Garics, Kone, Perez, Pazienza, Morleo; Diamanti; Bianchi
Napoli: Rafael; Maggio, Fernandez, Albiol, Reveillere; Inler, Dzemaili; Mertens, Pandev, Callejòn; Higuain