Gian Piero Gasperini is eager to trip up his former club, as an Inter side in crisis visit Genoa with Diego Milito and Rodrigo Palacio.
It kicks off at 14.00 GMT, click here for a match preview, as flood warnings have subsided in the city.
Gasp was famously fired only a few weeks into his tenure at San Siro and recently criticised the club, claiming they would have continued “not winning” had the Calciopoli scandal not destroyed Juventus in 2006.
He was also bitter that his three-man defence was discarded by an Inter side that now plays three at the back with Walter Mazzarri.
The Nerazzurri are struggling of late, as they were eliminated from the Coppa Italia by Udinese and picked up one victory since November.
In turn, Genoa needed a boost after last week’s 4-0 demolition job at the hands of Roma.
Mattia Perin is fit to start despite an injury problem over the last few days, but Francelino Matuzalem is banned with Daniele Portanova and Alessandro Gamberini sidelined.
Alberto Gilardino is back leading the attack after his one-match ban.
Fredy Guarin returns from suspension for Inter, but is left on the bench in favour of an all-Argentina front three of Ricky Alvarez and ex-Genoa stars Palacio and Milito.
Andrea Ranocchia is not even on the bench, fuelling reports of an imminent transfer to Borussia Dortmund.
Genoa: Perin; Antonini, De Maio, Marchese; Antonelli, Cofie, Fetfatsidis, Vrsaljko, Sturaro, Bertolacci, Gilardino
Genoa bench: Bizzarri, Donnarumma, Sampirisi, Biondini, Stoian, Calaiò, Centurion, De Ceglie, Sokoli, Konate, Tozser, Pierre
Inter: Handanovic; Campagnaro, Rolando, Juan Jesus; Jonathan, Kuzmanovic, Cambiasso, Nagatomo; Alvarez; Palacio, Milito
Inter bench: Carrizo, Castellazzi, Zanetti, Andreolli, Kovacic, Guarin, Mudingayi, Botta, Taider, Ranocchia, Samuel