Juventus are looking for a 13th consecutive victory, but face Lazio at the Olimpico days after they lost to Roma here.
It kicks off at 19.45 GMT, click here for the match preview.
The Bianconeri have won their last 12 Serie A outings on the bounce, but were knocked out of the Coppa Italia quarter-finals by Roma in this very stadium on Tuesday night.
Antonio Conte rotated his squad for that tie, resting Paul Pogba, Gigi Buffon, Carlos Tevez, Fernando Llorente, Stephan Lichtsteiner and Kwadwo Asamoah.
They are all back in the side this evening, although Giorgio Chiellini is suspended and replaced by Angelo Ogbonna, while Andrea Pirlo is rested.
Arturo Vidal and Tevez need to be careful, as a yellow card today will see them banned for next week’s clash against Inter.
Lazio are forced to reshuffle, as Stefan Radu and Ederson are injured, while Eddy Onazi, Senad Lulic and long-term absentee Stefano Mauri are banned.
Hernanes returns to the starting XI after his stunning late goal to beat Udinese 3-2 last week, a result secured after Lazio had gone down to 10 men.
Federico Marchetti was expected to be back in goal after suffering from a stomach bug, but he is again benched with Etrit Berisha starting. Abdoulay Konko is passed fit to start despite recent problems.
Juventus have a very strong record here against Lazio, not losing in Serie A since 2003 and winning six of the last eight. The Biancocelesti are unbeaten since Edy Reja took over with seven points from three rounds.
Lazio: Berisha; Biava, Cana, Dias; Cavanda, Ledesma, Biglia, Konko; Candreva, Hernanes; Klose
Lazio bench: Marchetti, Strakosha, Pereirinha, Novaretti, Ciani, Crecco, Vinìcius, Gonzalez, Felipe Anderson, Floccari, Keita, Perea
Juventus: Buffon; Barzagli, Bonucci, Ogbonna; Lichtsteiner, Vidal, Marchisio, Pogba, Asamoah; Tevez, Llorente
Juventus bench: Storari, Rubinho, Isla, Caceres, Peluso, Padoin, Pepe, Pirlo, Giovinco, Quagliarella