Clarence Seedorf aims to get Milan back on track against dangerous Cagliari, but Christian Abbiati misses out.
It kicks off at 14.00 GMT, click here for the full match report.
Once again the Stadio Sant’Elia only allows 5,000 fans in because of restructuring work, but the Sardinian supporters still tend to make themselves heard.
Since replacing Massimiliano Allegri two weeks ago, Seedorf has overseen a slender victory over Verona and a shock Coppa Italia exit to Udinese.
He is here without Christian Abbiati and Andrea Poli due to a flu epidemic, while Cristian Zapata and Stephan El Shaarawy are injured.
It means Marco Amelia is in goal for his first Serie A appearance of the season, as Allegri tended to favour Gabriel as his second choice.
Mario Balotelli is supported by Kaka, Keisuke Honda and Robinho with Adil Rami stepping into the back four.
Cagliari received a boost on Friday with news Mauricio Pinilla’s two-match ban had been halved on appeal, so he is available to start.
Victor Ibarbo is suspended with Nene sidelined.
Cagliari: Avramov; Pisano, Rossettini, Astori, Murru; Dessena, Conti, Ekdal; Cossu; Sau, Pinilla
Cagliari bench: Adàn, Perico, Del Fabro, Eriksson, Cabrera, Ibraimi, Solinas
Milan: Amelia; De Sciglio, Rami, Bonera, Emanuelson; De Jong, Montolivo; Honda, Kaka, Robinho; Balotelli
Milan bench: Gabriel, Coppola, Abate, Mexes, Constant, Cristante, Muntari, Birsa, Pazzini