There are three Serie A games today with Fiorentina visiting Cagliari and Milan hosting Torino before Sunday’s huge Juventus-Inter.
The round is spread out over three days, as the Genoa Derby has now been moved to Monday evening due to safety concerns.
It all begins today at 17.00 GMT with a double-header, as Fiorentina aim to continue their charge for Champions League places by visiting tricky customers Cagliari and Bologna-Udinese is an unexpected relegation six-pointer.
This evening Clarence Seedorf hopes to maintain his 100 per cent Serie A record, but is without Mario Balotelli against high-flying Torino.
On Sunday afternoon Napoli try to get back on track in Bergamo and Roma come face to face with Antonio Cassano’s on-form Parma, while Catania-Livorno smells of desperation.
Alberto Malesani makes his Sassuolo debut against his old club Verona and Lazio take on Chievo.
There can be no doubt about the biggest fixture of the weekend, as on Sunday night Juventus welcome arch rivals Inter in a game that got even spicier with recent transfer clashes.
The Derby della Lanterna concludes Week 22 on Monday at 19.45 GMT.