Alessandro Diamanti takes on Antonio Di Natale, as Bologna-Udinese is an unexpected relegation dogfight.
It kicks off at the Stadio Dall’Ara at 17.00 GMT, click here for a match preview.
Only two points separate these two teams going into Serie A Week 22 and they are both hovering precariously above the drop zone.
A defeat in this fixture could therefore have disastrous consequences.
Bologna have picked up since new Coach Davide Ballardini took over from Stefano Pioli, still unbeaten with three consecutive stalemates.
Udinese, on the other hand, have lost four Serie A rounds in a row, even if during that period they reached the Coppa Italia semi-final.
Diamanti leads the way for Bologna with Rolando Bianchi, who has rediscovered his form since bagging a brace against Napoli.
Bologna fans haven’t quite relaxed yet, as they know Guangzhou Evergrande are still eager to sign Diamanti and their transfer window is still open.
Marek Cech and Francesco Della Rocca are unavailable, but Panagiotis Kone is one to watch in midfield.
Udinese rely on hitman Di Natale with support from young Portuguese talent Bruno Fernandes.
Roberto Pereyra moves to the left flank with Andrea Lazzari preferred to Gianpiero Pinzi in the centre, as both Coaches opt for a 3-5-1-1 formation.
Bologna: Curci; Antonsson, Natali, Cherubin; Garics, Kone, Perez, Pazienza, Morleo; Diamanti; Bianchi
Udinese: Brkic; Heurtaux, Danilo, Domizzi; Basta, Badu, Allan, Lazzari, Pereyra; Bruno Fernandes, Di Natale
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more