Roma look to Francesco Totti, Gervinho and Miralem Pjanic against Antonio Cassano’s on-form Parma.
It kicks off at the Stadio Olimpico at 14.00 GMT, click here for a match preview.
There were fears the game would be delayed after flooding and torrential rain in Rome, but the concerns have now subsided.
The Giallorossi have closed the gap on leaders Juventus to six points and hope tonight Inter can do them a favour by taking a result in Turin.
First Rudi Garcia’s men must beat Parma, which is no easy feat, as the Ducali are unbeaten in 10 Serie A rounds and coming off four consecutive victories.
Totti lines up in attack with Gervinho and Alessandro Florenzi, while Pjanic is back in midfield despite injury concerns.
Federico Balzaretti, Dodo and new buy Rafael Toloi are unavailable along with the suspended Radja Nainggolan.
New signing Michel Bastos is on the bench.
Parma have defender Dias Felipe suspended with Joel Obi and Nicola Pavarini sidelined.
It is a return to the Olimpico for former Roma star Cassano, whose friendship with Totti was both intense and troubled.
He is partnered by Amauri with Italy international Marco Parolo and Uruguayan Walter Gargano in midfield.
Alessandro Lucarelli returns from suspension and Jonathan Biabiany starts despite being at the centre of a transfer deadline day tug-of-war between Milan, Lazio and Guangzhou Evergrande.
Roberto Donadoni adjusts to a 4-3-3 system to mirror Roma’s approach.
Parma prepared for this game by having a private audience with Pope Francis at the Vatican yesterday, marking the club’s Centenary year.
Their record in Rome is not impressive, winning just once in 24 official visits back in April 1997.
Roma: De Sanctis; Maicon, Benatia, Castan, Torosidis; Pjanic, De Rossi Strootman; Florenzi, Totti, Gervinho
Roma bench: Skorupski, Lobont; Ljajic, Taddei, Bastos, Destro, Jedvaj, Romagnoli, Battaglia, Ricci
Parma: Mirante; Cassani, Paletta, Lucarelli, Gobbi; Gargano, Marchionni, Parolo; Biabiany, Amauri, Cassano
Parma bench: Bajza, Coric; Molinaro, Galloppa, Cerri, Palladino, Schelotto, Munari, Mauri, Acquah, Rossini, Sall