Hernanes gets his debut and Fredy Guarin returns as Inter host Sassuolo hoping for their first win of 2014.
It kicks off at 19.45 GMT, click here for a match preview.
The Nerazzurri have not won a single game since Christmas between Serie A and the Coppa Italia, as last week they were thrashed 3-1 by Juventus.
Walter Mazzarri is under pressure, though President Erick Thohir released a statement reiterating his faith in the Coach.
Ricky Alvarez and Esteban Cambiasso are injured, so Diego Milito starts alongside Rodrigo Palacio.
Hernanes makes his debut in midfield following a transfer deadline day €20m move from Lazio.
It is also the comeback for Guarin, as the Colombian has been left out since his proposed switch to Juventus collapsed in January.
The midfielder had been distraught at the setback when his exchange with Mirko Vucinic had essentially been completed.
Mateo Kovacic is sent to the bench after Mazzarri’s criticism of his tactical errors against Juve.
Sassuolo are under new Coach Alberto Malesani, who lost his first match in charge with Verona.
The Neroverdi are in their debut Serie A season and famously lost 7-0 to Inter back in October, but the team has grown in confidence.
Since then they have been able to take points off Roma, Napoli and Lazio while a 4-3 victory over Milan saw Massimiliano Allegri sacked.
The one to watch is Italy Under-21 starlet Domenico Berardi, who scored all four goals against Milan.
He is partnered by January signing Sergio Floccari – a former teammate of Hernanes – while ex-Napoli captain Paolo Cannavaro is reunited with Mazzarri tonight.
Pedro Mendes sits out a ban with Francesco Magnanelli, Gaetano Masucci, Francesco Acerbi, Marius Alexe and Emanuele Terranova unavailable.
Inter: Handanovic; Rolando, Samuel, Juan Jesus; Jonathan, Hernanes, Kuzmanovic, Guarin, Nagatomo; Milito, Palacio
Inter bench: Castellazzi, Carrizo, Zanetti, Andreolli, Icardi, Kovacic, Campagnaro, Mudingayi, Botta, Taider, Ranocchia, D’Ambrosio
Sassuolo: Pegolo; Bianco, Cannavaro, Ariaudo; Rosi, Brighi, Marrone, Biondini, Longhi; Floccari, Berardi
Sassuolo bench: Polito, Pomini, Antei, Pucino, Gazzola, Ziegler, Chibsah, Missiroli, Sansone, Farias, Floro Flores, Zaza