Napoli need to beat Roma tonight to reach the Coppa Italia Final after a thrilling 3-2 away defeat in the first leg.
The decider kicks off at the Stadio San Paolo at 19.45 GMT. The winner will face Fiorentina in the Final in Rome.
Roma won the first leg 3-2 in a spectacular encounter, a result that means Napoli only need a 1-0 victory to go through on away goals.
There are reports Napoli legend Diego Armando Maradona will be in the stands tonight.
Gonzalo Higuain leads the way again with support from Dries Mertens, Jose Maria Callejon and Marek Hamsik.
Ex-Verona midfielder Jorginho starts with Gokhan Inler, as Valon Behrami is still not 100 per cent fit, with January signing Faouzi Ghoulam at left-back.
Napoli received a big boost to their confidence on Saturday night when fighting back to beat Milan 3-1 with a Higuain brace.
Roma’s winning streak was ended by rivals Lazio in a 0-0 draw in the Derby della Capitale on Sunday afternoon.
Radja Nainggolan is suspended for this Coppa Italia tie, so Miralem Pjanic completes the midfield with Daniele De Rossi and Kevin Strootman.
Francesco Totti seemed tired during the derby, so he is rested initially in favour of Mattia Destro with Adem Ljajic and Gervinho.
Dodo and Federico Balzaretti are still on the treatment table, but Morgan De Sanctis returns to face his former club.
Michel Bastos makes his first Roma start against Napoli, the club he seemed set to join before changing his mind in January.
It is also a reunion for Strootman and Mertens, who together were key figures at PSV Eindhoven last season.
The last time Roma played at the San Paolo was a 4-1 defeat in January 2013, including an Edinson Cavani hat-trick.
There are several players who will be suspended for the Final if they receive a yellow card tonight. They are Higuain, Raul Albiol and Jorginho for Napoli, Roma’s Mehdi Benatia and Alessandro Florenzi.
Napoli: Reina; Maggio, Fernandez, Albiol, Ghoulam; Inler, Jorginho; Mertens, Hamsik, Callejon; Higuain
Roma: De Sanctis; Torosidis, Benatia, Castan, Bastos; Pjanic, De Rossi, Strootman; Ljajic, Destro, Gervinho