Urby Emanuelson, Robinho and Daniele Bonera have joined the Milan injury list against Bologna.
The Serie A fixture kicks off on Friday at 19.45 GMT, click here for a match preview.
Clarence Seedorf welcomes Cristian Zapata back to the squad, but Emanuelson, Robinho and Bonera are on the treatment table.
They miss out along with longer-term absentees Stephan El Shaarawy, Bryan Cristante, Valter Birsa and Matias Silvestre.
This game is brought forward to Friday in order to help Milan prepare for next week’s Champions League Round of 16 tie with Atletico Madrid.
Milan squad for Bologna: Abbiati, Amelia, Gabriel, Abate, Constant, De Sciglio, Mexes, Rami, Zaccardo, Zapata, Essien, De Jong, Honda, Kakà, Montolivo, Muntari, Poli, Saponara, Taarabt, Balotelli, Pazzini