Tonight Vincenzo Montella’s Fiorentina host Walter Mazzarri’s Inter, while on Sunday it’s Juventus-Chievo, Sassuolo-Napoli and Roma-Sampdoria.
The round already began on Friday night with Milan-Bologna, so there is only one Saturday game at 19.45 GMT.
It sees Fiorentina host Inter in a head-to-head battle for European qualification and could see the return of Mario Gomez.
Sunday kicks off at 11.30 GMT with Edy Reja defending his unbeaten Serie A record away to a revived Catania.
Tomorrow afternoon leaders Juventus aim to get back on track against Chievo, while Napoli seek revenge after failing to beat Sassuolo earlier this season.
Atalanta pit their impressive home record against Parma, Cagliari welcome Livorno and Genoa take on Udinese.
On Sunday evening Roma try to recover from their Coppa Italia mauling, but must get past Sinisa Mihajlovic’s exciting Sampdoria side.
On Monday at 19.45 GMT the round concludes with Hellas Verona against Torino in a straight duel between the two revelations of this season.